Osteoarthritis and Genetics
Osteoarthritis is a common pain source. Almost everyone has symptoms by the age to 70. This problem is mainly due to joints wearing, trauma and aging. Although, physician have observed that some families seem to develop osteoarthritis (OA) early and in more joints than other families. Several genes have recently been linked to OA. Gene identification may open the door for additional therapies. One of the identified genes involves Nerve Growth Factor (NGF). An article in the New England Journal of Medicine discussed injection of an anti-NGF agent (Tanezumab) into the knee for pain treatment. The injection was associated with both decreased pain and improved function. Hopefully, these work will lead to both new treatment and research.
Tanezumab for the Treatment of Pain from Osteoarthritis of the Knee
Nancy E. Lane, M.D., Thomas J. Schnitzer, M.D., Ph.D., Charles A. Birbara, M.D., Masoud Mokhtarani, M.D., David L. Shelton, Ph.D., Mike D. Smith, Ph.D., and Mark T. Brown, M.D.
N Engl J Med 2010; 363:1521-1531October 14, 2010DOI: 10.1056/NEJMoa0901510