Brain Changes Predict Development of Chronic Pain
Changes in brain circuits are associated with the conversion of acute pain to chronic pain.
Nature Neuroscience. 2012;15(8):1117-1119.
The mechanism of brain reorganization in pain chronification is unknown. In a longitudinal brain imaging study, subacute back pain (SBP) patients were followed over the course of 1 year. When pain persisted (SBPp, in contrast to recovering SBP and healthy controls), brain gray matter density decreased. Initially greater functional connectivity of nucleus accumbens with prefrontal cortex predicted pain persistence, implying that corticostriatal circuitry is causally involved in the transition from acute to chronic pain. © 2012 Nature America, Inc. All rights reserved.